| The mechanism of bone loss after osteoporotic fracture may be related to factors such as decreased mechanical stimulation of osteocytes, related chemical signaling pathway proteins, inflammatory factors and related cytokines caused by disuse after fracture. The degree of systemic bone loss after fracture increases with age, fracture severity, and number of fractures, and the increased risk of systemic fracture after local fracture development reveals the systemic character of bone loss. In fact, the systemic bone loss after fracture may accelerate the progression of osteoporosis, and acute, progressive bone loss may have a range of negative effects, including osteoporotic bone pain, loosening of inserts or prostheses, periprosthetic fractures, and an increased risk of refractures. At present, the relevant mechanism and theoretical basis of bone loss caused by fracture are still in the exploration stage, and RAP and SAP theory, bone repair mineral demand theory and bone repair reserve theory provide a more reasonable explanation for bone loss after fracture. |