非酒精性脂肪肝与骨质疏松——从临床到分子
Non-alcoholic fatty liver disease and osteoporosis: From clinical observation towards molecular understanding
  
DOI:10.3969/j.issn.1006-7108.2024.05.024
中文关键词:  非酒精性脂肪肝  骨质疏松  骨代谢  分子机制
英文关键词:non-alcoholic fatty liver disease  osteoporosis  bone metabolism  molecular mechanism
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莫亮1 黄予心1 王章正1 李健雄2* 1.广州中医药大学广东 广州 510405 2.中山市人民医院康复医学科广东 中山 528400 
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中文摘要:
      肝脏和骨骼代谢之间的相互作用对维持机体代谢稳态具有重要作用。非酒精性脂肪肝病(non-alcoholic fatty liver disease, NAFLD)和骨质疏松(osteoporosis, OP)是常见的慢性肝脏和骨骼疾病,近年来许多研究提示NAFLD患者中OP发病风险增加,然而NAFLD合并OP的病理机制尚不明确。本文综述了近年来的相关研究,探讨了NAFLD和OP的临床关系,及NAFLD病理状态下可能对骨代谢造成影响的分子基础,包括炎症因子、骨桥蛋白(OPN)、骨保护素(OPG)、胎球蛋白A(fetuin-A)、胰岛素样生长因子1(IGF-1)、脂联素(Adiponectin)、卵磷脂胆固醇酰基转移酶(LCAT)和维生素D。本研究旨在总结NAFLD合并OP的相关研究进展,以期为相关实验研究及临床防治提供新思路。
英文摘要:
      The interaction between hepatic and skeletal metabolism plays a crucial role in maintaining metabolic homeostasis in the body. Non-alcoholic fatty liver disease (NAFLD) and osteoporosis (OP) are common chronic diseases affecting the liver and skeletal system, respectively. Recent studies have indicated an increased risk of developing OP in NAFLD patients, although the underlying mechanisms remain unclear. In this review, we summarize the latest research findings and explore the clinical relationship between NAFLD and OP. Furthermore, we delve into the molecular basis by which hepatic metabolic disturbances in NAFLD may impact bone metabolism. Key molecular factors implicated in this interaction include inflammatory cytokines, osteoprotegerin (OPG), osteopontin (OPN), fetuin-A, insulin-like growth factor-1 (IGF-1), adiponectin, lecithin cholesterol acyltransferase (LCAT) and vitamin D. The aim of this study is to summarize the current research progress on NAFLD combined with OP, in order to provide new insights for future experimental research and clinical interventions.
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