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| SARMs在肌少症治疗中的机制与进展 |
| Therapeutic prospects of SARMs in sarcopenia |
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| DOI：10.3969/j.issn.1006-7108.2024.05.027 |
| 中文关键词: 肌少症 选择性雄激素受体调节剂 雄激素 雄激素受体 |
| 英文关键词:sarcopenia therapeutic drugs SARMs androgen androgen receptors |
| 基金项目:昆山市骨质疏松性骨质防治重点实验室（KZ2023005）；2021年江苏省卫生健康委员会医学科研项目（Z2021026）；2021年昆山市科技专项项目（KSZ2155） |
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| 中文摘要: |
| 肌少症(sarcopenia)是当前一类严重影响老年人的日常行为能力和生活质量的疾病。因其发病率逐年增多，近些年各专家对于肌少症的研究也逐步深入。肌少症的治疗方法和治疗药物的研究备受关注，其中，选择性雄激素受体调节剂（selective androgen receptor modulators，SARMs）是一大研究热点，本篇综述的主要目的是探讨SARMs在肌少症的发生发展中的作用机制、研究和临床进展，以便于未来能更快更好地应用于临床治疗。 |
| 英文摘要: |
| Sarcopenia is a current group of diseases that seriously affect the daily behavior ability and quality of life of the elderly. Because its incidence has increased year by year, the research of various experts on sarcopenia has gradually deepened in recent years. The research on the treatment methods and therapeutic drugs of sarcopenia has attracted much attention, among which Selective Androgen Receptor Modulators (SARMs) is a major research hotspot, the main purpose of this review is to explore the mechanism of action of SARMs in the occurrence and development of sarcopenia, research and clinical progress, so that it can be applied to clinical treatment faster and better in the future. |
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