从“肾藏精”理论探析肾调控免疫系统影响骨代谢
Theoretical exploration of kidney influence on the bone metabolism by regulating immune system based on the theory of "Kidney stores essence"
  
DOI:10.3969/j.issn.1006-7108.2024.06.013
中文关键词:  肾藏精  骨质疏松症  骨免疫  骨代谢  中医中药
英文关键词:kidney stores essence  osteoporosis  osteoimmunology  bone metabolism  traditional Chinese medicine
基金项目:国家自然科学基金(81973719);辽宁省应用基础研究计划(2022JH2/101300105); 沈阳市中青年科技创新人才计划(RC200160)
作者单位
孙秀颖 杨芳* 辽宁中医药大学辽宁 沈阳 110847 
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中文摘要:
      目的 基于免疫系统对骨代谢的影响,从“肾藏精”理论出发,分析通过肾调控免疫系统改善骨代谢以防治骨质疏松症的可行性,以期为骨质疏松症的深入研究及防治提供更多的思路。方法 通过检索中国知网、Pubmed等数据库中有关免疫系统与骨代谢的文献,探讨免疫系统与骨代谢的联系;通过查阅中医古籍中“肾藏精”相关的论述,探讨肾与免疫系统的联系。结果 免疫细胞源于骨髓,且免疫细胞、免疫分子均可影响骨代谢。肾因其“主藏精”的功能,可通过“阴阳之宅”、主骨化血、化髓上通于脑等方式与免疫系统密切相关。结论 基于免疫系统对骨代谢的影响和“肾藏精”理论,通过肾调控免疫系统改善骨代谢从而防治骨质疏松症在理论上具有可行性,值得进一步深入研究。
英文摘要:
      Objective Based on the influence of the immune system on bone metabolism, this paper analyzed the feasibility of improving bone metabolism through kidney regulation of the immune system to prevent and control Osteoporosis from the theory of "kidney stores essence", with the aim of providing more ideas for in-depth research and prevention of Osteoporosis. Methods The connection between the immune system and bone metabolism was explored by searching the literature on CNKI and Pubmed databases about the immune system and bone metabolism, and the connection between the kidneys and the immune system was explored by reading the traditional Chinese medical literature on the theory of "kidney stores essence". ResultsImmune cells originate from bone marrow, and immune cells and immune cytokines can affect bone metabolism. The kidney, due to its function as "storing essence", is closely related to the immune system through its role as the "house of yin and yang", masteing bone and transforming into the blood, and transforming into the marrow up to the brain. Conclusion Based on the influence of the immune system on bone metabolism and the theory of "kidney stores essence", it is theoretically feasible to improve bone metabolism through kidney regulation of the immune system to prevent and treat Osteoporosis, which is worthy of further in-depth study.
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