免疫细胞介导的炎症与骨质疏松症的机制与作用途径
Immune cell-mediated inflammation and osteoporosis: Mechanisms and pathways
  
DOI:10.3969/j.issn.1006-7108.2024.06.015
中文关键词:  骨质疏松症  绝经后骨质疏松症  免疫细胞  骨代谢
英文关键词:osteoporosis  postmenopausal osteoporosis  immune cells  bone metabolism
基金项目:国家自然科学基金项目(81974564,82104730);中原英才计划-科技创新领军人才项目(224200510027);河南省中医药科学研究专项(2021ZY2159,2019JDZX2032,2021ZPZX021)
作者单位
刘雅利1 封俨宸1 党雪1 刘飞祥2* 林子璇2 张运克1 车志英1 1.河南中医药大学河南 郑州 450046 2.河南中医药大学第一附属医院河南 郑州 450000 
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中文摘要:
      骨质疏松症(osteoporosis,OP)是常见的骨骼疾病,其主要特征是骨组织显微结构的破坏和骨密度的降低。树突状细胞、NK细胞、淋巴细胞等先天免疫细胞和适应性免疫细胞与骨细胞发生相互关联作用,参与调节炎症反应和免疫调节过程,影响了OP的发生发展。研究分别系统梳理先天和适应性免疫细胞主要通过产生各种因子和其他免疫细胞相互作用直接或间接介导的炎症反应作用于骨代谢的机制,以期为OP的防治提供参考。
英文摘要:
      Osteoporosis (OP) is a common bone disease characterized by the destruction of bone microstructure and the decrease of bone density. Dendritic cells, NK cells, lymphocytes and other innate immune cells and adaptive immune cells interact with bone cells, participate in the regulation ofinflammatory response and immune regulation, and affect the occurrence and development of OP. Thisstudy systematically sorted out the mechanism of innate and adaptive immune cells acting on bone metabolism by directly or indirectly mediating the inflammatory response through the interaction of various factors and other immune cells, in order to provide reference for the prevention and treatment of OP.
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