内皮细胞Piezo1调控H型血管生成在骨质疏松症病理机制中的意义
Significance of Piezo1 of endothelial cells in regulating H-type vessels in the pathogenesis of osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2024.06.017
中文关键词:  内皮细胞  Piezo1  骨质疏松症  H型血管
英文关键词:endothelial cells  Piezo1  o steoporosis  type H vessels
基金项目:国家自然科学基金面上项目(82374470)
作者单位
张华1 何琪1 杨均政1 陈柏豪1 陈楚仪1 池伟进1 潘兆丰1 肖嘉聪1 黎淼1 黎少聪1 林跃玮1 王璠琛1 王薪添1 曾嘉旭1 王海彬2 孟凯3 陈鹏2* 1.广州中医药大学第一临床医学院广东 广州 510405 2.广州中医药大学第一附属医院骨科广东 广州 510405 3.山东中医药大学附属医院骨科山东 济南 250014 
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中文摘要:
      内皮细胞(endothelial cells,ECs)缺失Piezo1不仅能影响骨重塑导致骨量丢失、加重骨质疏松症,而且能引起H型血管的减少;H型血管调控的成骨-成血管偶联失衡在骨质疏松症的发病过程中起到关键作用。Piezo1为治疗骨质疏松症提供了分子层面的新思路和新视角。笔者主要对Piezo1蛋白介导的H型血管生成的机制作一综述,总结近年来关于骨质疏松症及内皮细胞Piezo1的最新研究进展,为骨质疏松症的治疗提供新的临床见解和理论依据。
英文摘要:
      The loss of Piezo1 of endothelial cells (ECs) not only affects bone remodeling, leading to bone loss and aggravating OP, but also causes the decrease of Type H Vessels. The imbalance of osteogenic-angiogenic coupling regulated by Type H Vessels plays an important role in the pathogenesis of OP. Piezo1 offers new ideas and perspectives at the molecular level for treating osteoporosis.This article mainly reviews the mechanism of Piezo1 mediated Type H Vessels in OP treatment and summarizes the latest research advance of Piezo1 on osteoporosis and endothelial cells, providing theoretical basis for clinical treatment of osteoporosis.
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