铁死亡在类风湿性关节炎中的研究进展
Research progress of ferroptosis in rheumatoid arthritis
  
DOI:10.3969/j.issn.1006-7108.2024.06.020
中文关键词:  类风湿性关节炎  铁死亡  铁蓄积  脂质过氧化  氧化应激
英文关键词:rheumatoid arthritis  ferroptosis  iron accumulation  lipid peroxidation  oxidative stress
基金项目:黑龙江省重点研发计划(GZ20210);黑龙江省中医药科研课题项目(ZHY2023-011); 2022年国家名老中医药专家工作室传承项目
作者单位
李朝霞1 高鲁2* 张晓峰1 杜佳哲1 徐西林3 1.黑龙江中医药大学黑龙江 哈尔滨 150040 2.黑龙江中医药大学附属第二医院黑龙江 哈尔滨 150006 3.黑龙江中医药大学附属第三医院黑龙江 哈尔滨 150030 
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中文摘要:
      类风湿性关节炎(rheumatoid arthritis,RA)是一种慢性自身免疫性疾病,其特征是关节炎症、进行性软骨破坏、骨侵蚀。最近的研究表明,铁死亡参与自身免疫性肝炎、类风湿性关节炎等自身免疫性疾病的发生和发展。该综述重点围绕铁死亡的机制及其与RA发病机制的关联,探讨靶向铁死亡的疗法为RA患者治疗提供新的理论基础和潜在治疗方法。
英文摘要:
      Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, progressive cartilage destruction and bone erosion. Recent studies have shown that ferroptosis is involved in the progression of autoimmune diseases such as autoimmune hepatitis and rheumatoid arthritis. In this review, we focus on the mechanism of ferroptosis and its association with the pathogenesis of RA, and explore the new theoretical basis and potential therapeutic methods of targeted ferroptosis for the treatment of RA patients.
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