| Resveratrol(RES)has a variety of pharmacological activities. Resveratrol is a natural plant antitoxin polyphenol, which mainly mediates FoxO3a protein and NF- κB/RANKL signal through Sirt1 protein. Wnt/ β-catenin, PI3K/AKT, MAPK signal pathway, estrogen receptor, AMPK and oxidative stress affect osteoblast differentiation, inhibit osteoclast formation, improve bone joint tissue structure and bone loss, improve osteoporosis and protect bone health. Resveratrol increases bone growth and reduces bone loss in the elderly and postmenopausal people. It may be a new potential drug for the treatment of osteoporosis in the future. In this paper, CNKI, Chinese Medical Journal full-text Database, WANFANG DATE, PubMed and Web of Science databases were used to search the literature reports on the prevention and treatment of OP by RES in the last 10 years, and the mechanism of RES in preventing and treating OP was reviewed in many aspects, in order to provide new ideas and directions for the clinical application of resveratrol in the future. |