女贞子防治骨质疏松症药理机制的研究
Research on the pharmacological mechanism of fructus ligustri lucidi in the prevention and treatment of osteoporosis
  
DOI:10.3969/j.issn.1006-7108.2024.06.028
中文关键词:  女贞子  骨质疏松症  肾性骨病  作用机制
英文关键词:fructus ligustri lucidi  osteoporosis  renal osteodystrophy  mechanism of action
基金项目:
作者单位
吴爽 赵悦彤 路晓洁 刑云泽 杨波* 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津 300193 
摘要点击次数: 38
全文下载次数: 0
中文摘要:
      骨质疏松症是常见的骨代谢疾病,随着中国人口老龄化程度的不断加重,已成为广泛关注的公共健康问题。女贞子作为传统的补肾中药,对骨质疏松症的治疗有着独特优势。研究显示女贞子具有骨保护作用,能够减少骨质流失,改善骨质疏松症,但其作用机制尚不清晰。为此,本文利用中国知网、PubMed等数据库,以骨质疏松、女贞子、成骨等为关键词,检索了近15年国内外相关文献。根据现有研究,本文主要从钙平衡、氧化应激、骨代谢及激素样作用四个方面综合论述女贞子防治骨质疏松症的机制,以期为女贞子抗骨质疏松的进一步研究提供参考及为中药防治骨质疏松症提供思路。
英文摘要:
      Osteoporosis (OP) is a common bone metabolic disease. With the increase of aging in China, OP is a public health problem that is widely concerned in China today. Fructus ligustri lucidi (FLL), as a kidney-tonifying traditional Chinese medicine, is widely used in clinical practice and has unique advantages in the prevention and treatment of OP. Research has shown that FLL extract has a bone protective effect and reduces bone loss. However, its mechanism of action is not completely clear. Hence, this article employs databases like CNKI and PubMed to conduct a comprehensive search for pertinent domestic and international literature published within the last 15 years, utilizing keywords such as OP, FLL, osteogenesis, among others. Drawing upon existing research, this article primarily examines the preventive and therapeutic mechanism of FLL in relation to OP, including calcium balance, oxidative stress, bone metabolism, and parahormone effect. The aim is to furnish a foundation for future investigation on the role of FLL in preventing and treating OP, while also offering insights into the potential of traditional Chinese medicine in addressing this condition.
查看全文  查看/发表评论  下载PDF阅读器
关闭
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=FC9DA7BF2F842A3B052390CAC8D82FD0111512ED1A63E6D2BF191092934797C254AF607EF335CF749FFED4A23C6EBE758018752C050AF09AA8D283790A2A89BFEACE28CEECF7BA037D61BEDF56E5C0A6C943722AF214702C3813EC0FC7DBF86F556F2D6EF7C2653A3EF48FDAC823C75F362A15A99F90D27D&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=527A01A248DACB72&jid=CA678592D11E309E8E3FB3B2BFE9BE1A&yid=B80136CCD8DCBAA1&aid=&vid=&iid=B31275AF3241DB2D&sid=8587C7CAA7A3D0DB&eid=66973F362693F62B&fileno=202406028&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="527A01A248DACB72"; var my_jid="CA678592D11E309E8E3FB3B2BFE9BE1A"; var my_yid="B80136CCD8DCBAA1"; var my_aid="";