| Pyroptosis is a programmed cell death with inflammatory response. Gasdermin D (GSDMD) is a key protein that mediates pyroptosis and is the main executor. When inflammasomes are stimulated by pathogenic microorganisms, the pyroptosis signal caspase is activated, which cuts GSDMD. Then the amino terminal (N terminal) of GSDMD is transferred to the cell membrane to form intracellular pores that allow water molecules and other substances to enter, causing cell swelling and cracking, leading to cell death, that is, cell pyroptosis. In recent years, scientific research has demonstrated that GSDMD may be involved in the pathogenesis of bone metabolic diseases, especially osteoporosis, by mediating osteoblast pyroptosis. Inhibition of osteoblast pyroptosis may regulate the development of osteoporosis. Osteoblast pyroptosis may interfere with bone metabolism as a pro-inflammatory way to regulate osteocyte death, and its research is a new research hot spot. In this paper, the molecular mechanism of GSDMD-mediated osteoblast pyroptosis is analyzed and discussed, and the relationship between GSDMD-mediated osteoblast pyroptosis and the field of cell pyroptosis is reviewed. The relationship between osteoblast pyroptosis and osteoporosis is analyzed, which provides a key target protein factor mechanism for the research and diagnosis and treatment of osteoporosis. |