| Bone homeostasis is a dynamic regulation process of bone resorption by osteoclasts and bone formation by osteoblasts. It is the basis for the normal development of human bones. The imbalance of bone homeostasis affects the occurrence and development of many orthopedic diseases. However, the regulatory mechanism of bone homeostasis is relatively complex and has not yet been fully elucidated. In recent years, research has found that osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells play a crucial role in regulating bone homeostasis. Efferocytosis maintains the normal function of osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells, promotes bone homeostasis, inhibits bone loss, and enhances bone strength. In this paper, the mechanism of efferocytosis is elaborated, and the relationship between osteoblasts, osteoclasts and bone marrow mesenchymal stem cells efferocytosis and bone homeostasis is summarized, in order to provide a new perspective for the study of regulating bone homeostasis and preventing and treating bone metabolism-related diseases. |