| Rheumatoid arthritis (RA) is an autoimmune disease that causes joint inflammation and pain, impairs joint function, and causes deformity. To date, there is no complete cure for RA. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway has been identified as an important pathway for the prevention and treatment of RA. The PI3K/Akt signaling pathway is involved in a number of biological processes, including cell survival, proliferation, and inflammatory responses. It plays a key role in the development of RA by regulating the production of inflammatory mediators, influencing cellular autophagy and osteoclast differentiation, regulating apoptosis, mediating cell migration and infiltration, and regulating angiogenesis and permeability. Modulation of this signaling pathway may help to control inflammation, to slow down joint damage, and to promote tissue repair, thus improving patients' quality of life. Drug development targeting to PI3K/Akt signaling pathway is an important way to explore effective prevention and treatment of RA. By reviewing a large number of literature reports, this paper describes the research progress of the role of PI3K/Akt signaling pathway in the development of RA, with the aim of providing insight into the pathogenesis of RA and the development of new drugs and treatments in the future, and even more, to provide reference for future clinical practice and research. |