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| “miRNA-肠道微生物群”功能轴对骨质疏松症的影响机制 |
| Exploration of the mechanism of osteoporosis based on the functional axis of miRNA-intestinal microbiota |
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| DOI：10.3969/j.issn.1006-7108.2024.07.022 |
| 中文关键词: miRNA 肠道微生物群 骨质疏松症 骨代谢 |
| 英文关键词:miRNA intestinal microbiota osteoporosis bone metabolism |
| 基金项目:甘肃省教育科技创新项目（2022A-067）；甘肃省高等学校创新基金（2023A-088）；甘肃省自然科学基金（22JR5RA582）；甘肃省科技计划项目重点研发计划国际科技合作类（23YFWA0005）；重庆医科大学未来医学青年创新团队支持计划(W0019) |
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| 中文摘要: |
| 骨质疏松症(osteoporosis，OP)是一种以骨质减少、骨微结构破坏为特征的系统性骨病，其发病机制涉及遗传、环境和生物多种因素的相互作用。近年来，微小RNA(miRNA)与肠道微生物群(gut microbiota，GM)在其中的影响越来越引人关注。miRNA通过调控成骨细胞介导的骨形成和破骨细胞介导的骨吸收干预OP的进程，而GM则通过调节免疫反应、代谢功能、激素平衡等多重途径影响骨代谢。笔者旨在深入剖析“miRNA-肠道微生物群”功能轴对OP的作用机制，为OP的预防和治疗提供参考依据。 |
| 英文摘要: |
| Osteoporosis, a systemic bone disease characterized by bone loss and destruction of bone microstructure, is driven by a complex interplay of genetic, environmental, and biological factors. Recently, miRNA and intestinal microbiota have emerged as key factors in the pathogenesis of osteoporosis, garnering increasing attention. Specifically, miRNA influences osteoporosis development by modulating osteoblast-mediated bone formation and osteoclast-mediated bone resorption, while intestinal microbiota impacts bone metabolism through the regulation of immune response, metabolic function, hormone balance, and other complex pathways. This article aims to analyze the functional axis of the miRNA-intestinal microbiota in osteoporosis, shedding light on its mechanism and providing valuable insights for the prevention and treatment of osteoporosis. |
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