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| 骨小梁分数在成都地区人群中变化及临床应用精确度评估 |
| Changes of trabecular bone scorein the population of Chengdu and assessment of the precision in clinical application |
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| DOI：10.3969/j.issn.1006-7108.2024.08.013 |
| 中文关键词: 骨小梁评分；双能X射线吸收法 骨密度；精确度误差 |
| 英文关键词:dual-energy X-ray absorptiometry trabecular bone score bone density precision error |
| 基金项目:四川省医学科学院·四川省人民医院临床研究及转化基金（2017LY01） |
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| 中文摘要: |
| 目的 观察骨小梁分数（trabecular bone score，TBS）在成都地区人群中的分布及变化；评估TBS用于骨质疏松症治疗监测的精确度。方法 选择2022年10月至2023年7月在四川省医学科学院·四川省人民医院就诊或体检者4 963例，其中女性3 708人，男性1 255人，均行双能X线(DXA)检查测量腰椎TBS及骨密度(bone mineral density, BMD)，结果以均值±标准差(SD)表示。选取30例患者每人行两次DXA检查，计算BMD、TBS的精确度误差。结果 ①TBS在男性20~29岁、女性30~39岁时达到峰值，之后均随增龄逐渐下降；②男、女TBS与年龄呈负相关，与体质量指数(body mass index, BMI)呈弱正相关；TBS与L1~4 BMD呈正相关；③低骨量组男、女TBS受损者占比分别为19.6 %、35.1 %；BMD正常TBS受损+部分受损者占比分别为22.9 %、40.5 %。L1~4 BMD的CV %和LSC-CV %分别为1.089 %、3.015 %；TBS的CV %和LSC %分别为1.429 %、3.958 %。结论 ①本组TBS数据为成都地区人群骨质疏松防治、骨折风险评估提供了参考依据，随增龄BMD、TBS逐渐丢失，以女性更为明显；②TBS有较好的精确度，可用于骨质疏松症的治疗监测。 |
| 英文摘要: |
| Objective To observe the distribution and changes of trabecular bone score (TBS) in the population of Chengdu
region. To evaluate the precision of TBS for monitoring osteoporosis treatment. Methods A total of 4 963 patients，
including 3 708 females and 1 255 males were selected from October 2022 to July 2023. Dual energy X-ray
Absorptiometry (DXA) examination were performed to measure lumbar BMD and TBS.The results were expressed as
mean ± standard deviation (SD). 30 patients were selected to undergo two DXA examinations each.The precision errors of
BMD and TBS were calculated. Results ①The TBS reaches its peak in males aged 20-29 and females aged 30-39, and
Gradually decreases with age thereafter. ② TBS were negatively correlated with age and weakly positively correlated with
BMI both in male and female. TBS was positively correlated with L1-4 BMD. ③Theproportion of degraded TBS in male
and female in low bone mass group were 19.6 % and 35.1 %, respectively；The proportion of degraded or partially
degraded TBS in men and women with normal BMD were 22.9 % and 40.5 %，respectively. The CV % and LSC-CV % of
L1-4 BMD were 1.089 % and 3.015 %，respectively；and in TBS were 1.429 % and 3.958 %, respectively. Conclusion
①This group of TBS data provided a reference basis for treatment of osteoporosis and the risk assessment of fractures for
the population in Chengdu region. BMD and TBS gradually losed with age，especially in women. ②TBS has good
precision and can be used for monitoring the treatment of osteoporosis. |
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