| Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extraterminal domain family, playing a crucial role in the regulation of gene transcription, cell proliferation, apoptosis, and inflammation. BRD4 has been closely linked to various diseases, including cancer, neurological disorders, and viral infections. Although BRD4 has obtained significant attention in the field of cancer research, limited investigation has been conducted regarding its implications in bone-related diseases, encompassing osteoarthritis, intervertebral disc degeneration, osteoporosis, and bone tumors, among others. Recent research has indicated the involvement of BRD4 in the pathogenesis of bone-related diseases, highlighting its significant role. Therefore, this review summarizes the research results of BRD4 and its inhibitors in bone-related diseases in recent years. By expounding the structure and function of BRD4 and the role of BRD4 and its inhibitors in bone-related diseases, it is suggested that BRD4 may be a potential target for the treatment of bone-related diseases. |