中国骨质疏松杂志

饮食炎症指数与高血压患者骨质疏松症的关系NHANES数据分析

Analysis of NHANES data on the relationship between dietary inflammation index and osteoporosis in hypertensive patients

DOI：10.3969/j.issn.1006-7108.2024.09.015

中文关键词: 骨质疏松症高血压饮食炎症指数数据库

英文关键词:osteoporosis hypertension dietary inflammatory index database

基金项目:基金项目：河南省医学科技攻关计划联合共建项目（LHGJ20230492）；洛阳市社会发展公益专项（医疗卫生）重点项目（2302020A）基金项目：河南省医学科技攻关计划联合共建项目（LHGJ20230492）；洛阳市社会发展公益专项（医疗卫生）重点项目（2302020A）

作者	单位
李炜1 宋朝功2 王许可3*	1.河南推拿职业学院中医骨伤教研室，河南洛阳 410023 2.河南推拿职业学院中医临床教研室，河南洛阳 410023 3.河南省洛阳正骨医院（河南省骨科医院）脊柱外科中心脊柱微创一科，河南洛阳 410023

摘要点击次数: 552

全文下载次数: 0

中文摘要:

目的　基于国家健康与营养调查（NHANES）数据库探讨饮食炎症指数（DII）与高血压患者骨质疏松症（OP）的关系。方法　以参与2013—2014年、2017—2018年NHANES的高血压患者为研究对象，最终纳入1 667例。根据DII的四分位数将高血压患者分为DII Q1组、DII Q2组、DII Q3组、DII Q4组。采用Logistic回归分析探讨DII与OP的关系，并行趋势分析。采用亚组Logistic回归分析不同性别中DII与高血压患者OP的相关性。采用限制性立方样条图（RCS）分析DII与高血压患者OP风险的量效关系。结果　DII Q1组、DII Q2组、DII Q3组、DII Q4组高血压患者OP患病率为35.49 %（148/417）、38.13 %（159/417）、42.93 %（179/417）、47.36 %（197/416），差异有统计学意义（ χ2=14.240，P=0.003）。校正全部混杂因素后，DII与高血压患者OP风险仍显著相关（OR=1.017，95 %CI：1.005~1.029，P＜0.05）；相比DII Q1组，DII Q3组、DII Q4组高血压患者患OP风险增高0.752倍、2.261倍（P＜0.05）。性别分层后，女性高血压患者中DII Q1组、DII Q2组、DII Q3组、DII Q4组的OP风险OR值呈增加趋势（P趋势＜0.001）。RCS分析显示，在高血压患者中，DII与OP风险呈非线性关系（P非线性=0.014）。结论　DII是高血压患者OP的独立危险因素，DII水平越高，OP的风险越高。

英文摘要:

Objective To explore the association between dietary inflammatory index (DII) and osteoporosis (OP) in patients with hypertension based on the National Health and Nutrition Examination Survey（NHANES）database. Methods Patients with hypertension who participated in the NHANES from 2013-2014 and 2017-2018 were studied. A total of 1667 cases were finally included, and relevant data were collected and analyzed. The patients with hypertension were categorized into DII Q1, DII Q2, DII Q3, and DII Q4 groups based on the quartiles of DII. Logistic regression analysis was used to explore the relationship between DII and OP with trend analysis. Subgroup logistic regression was used to analyze the correlation between DII and OP in patients with hypertension in different genders. Restricted cubic spline plots (RCS) were used to analyze the quantitative and qualitative relationship between DII and OP risk in patients with hypertension. Results The prevalence of OP in patients with hypertension in DII Q1, DII Q2, DII Q3, and DII Q4 groups was 35.49% (148/417), 38.13% (159/417), 42.93% (179/417), and 47.36% (197/416), respectively, with a statistically significant difference (=14.240, P=0.003). After correcting for all confounders, DII was still significantly associated with the risk of OP in patients with hypertension (OR=1.017, 95% CI: 1.005-1.029, P<0.05). Compared to that in the DII Q1 group, the risk of OP in patients with hypertension in the DII Q3 group and DII Q4 group increased by 0.752-fold and 2.261-fold, respectively (P<0.05). After gender stratification, there was a trend of increasing OR for OP risk in the DII Q1, DII Q2, DII Q3, and DII Q4 groups among female patients with hypertension (Pfor trend<0.001). RCS analysis showed a nonlinear association between DII and OP risk in patients with hypertension (P nonlinear=0.014). Conclusion　DII is an independent risk factor for OP in hypertensive patients. The higher the DII level is, the higher the risk of OP.

查看全文查看/发表评论下载PDF阅读器

关闭