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| microRNAs在骨质疏松症发生发展中的研究进展 |
| Research progress on bone homeostasis regulatory factors microRNAs in the occurrence and development of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2024.09.024 |
| 中文关键词: microRNAs 骨质疏松症 成骨细胞 破骨细胞 |
| 英文关键词:microRNAs osteoporosis osteoblast osteoclast |
| 基金项目:基金项目：甘肃省中医药管理局科研课题（GZK-2019-19） |
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| 中文摘要: |
| 骨质疏松的发生是由于成骨细胞介导的骨形成和破骨细胞介导的骨吸收平衡被打破，而使骨稳态出现异常。骨稳态调节因子microRNAs作为表观调控因子，通过调控成骨细胞和破骨细胞的相关信号分子的表达，使其在骨代谢中发挥重要作用。本文就microRNAs在骨质疏松症中参与调节维持骨微环境的细胞分化、增殖、自噬和在相关信号分子、相关信号通路的表达等方面最新研究进展进行综述，并总结了microRNAs在骨细胞分化中的作用，突出了microRNAs在代谢性骨疾病中作为治疗靶点的潜力。 |
| 英文摘要: |
| The occurrence of osteoporosis is due to the disruption of the balance between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts， resulting in abnormal bone homeostasis. MicroRNAs， as epigenetic regulatory factors，play an important role in bone metabolism by regulating the expression of signaling molecules related to osteoblasts and osteoclasts. This article reviews the latest research progress on the role of microRNAs in regulating and maintaining cell differentiation，proliferation，autophagy，and expression of related signaling molecules and pathways in bone microenvironment in osteoporosis，and summarizes the role of microRNAs in bone cell differentiation，highlighting the potential of microRNAs as therapeutic targets in metabolic bone diseases. |
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