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| AGE-RAGE在骨质疏松症中的作用 |
| The role of AGE-RAGE in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2024.10.014 |
| 中文关键词: 糖基化 成骨细胞 破骨细胞 骨髓间充质干细胞 |
| 英文关键词:glycosylation osteoblast osteoclast bone marrow mesenchymal stem cells |
| 基金项目:国家自然科学基金（81960877）；甘肃省高等学校创新基金（2021A-076，2023A-088）；甘肃省科技计划（创新基地和人才计划）项目（21JR7RA561）；敦煌医学与转化教育部重点实验室开放课题(DHYX20-16，DHYX21-01，DHYX21-07，HYX22-05)；甘肃省中医药研究中心专项开放课题（zyzx-2020-zx10）；甘肃省自然科学基金（21JR1RA267，22JR5RA582）；甘肃省教育科技创新项目（2022A-067）；甘肃省科技计划项目重点研发计划国际科技合作类（23YFWA0005） |
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| 中文摘要: |
| 糖基化是一种非酶化学反应，其中巯基蛋白键被葡萄糖取代，导致正常细胞和组织功能受损。骨质疏松症是一个主要的公共卫生负担，随着全球人口老龄化，预计将进一步增加。在过去的20年中，糖基化终产物(advanced glycation end products，AGEs)已被证明是骨质疏松症和其他与衰老相关的慢性退行性疾病的发病和发展的关键介质。骨内AGE的积累诱导胶原蛋白和其他骨蛋白形成共价交联，影响组织的力学特性，扰乱骨重塑和退化，导致骨质疏松。另一方面，糖基化终产物受体(receptor for advanced glycation endproducts，RAGE)是一种膜蛋白，AGE-RAGE与骨退化有关。氧化应激促进AGE的形成，抑制正常的酶促交联，并降解胶原结构，降低抗骨折性。然而，骨质疏松症中AGE其受体RAGE的关系尚不清楚。因此，该综述旨在阐明糖基化终产物介导AGE-RAGE信号通路在骨质疏松症细胞中的生物学作用。 |
| 英文摘要: |
| Glycosylation，a non-enzymatic chemical process replacing sulfhydryl protein bonds with glucose，leads to impaired cellular and tissue function. Osteoporosis，a significant public health concern，is anticipated to escalate with the aging global population. Over the last two decades，advanced glycation end products (AGEs) have emerged as crucial factors in the onset and progression of osteoporosis and other age-associated chronic degenerative conditions. The accumulation of AGEs in bone triggers collagen and bone protein cross-linking，altering tissue mechanics，disrupting bone remodeling，and contributing to osteoporosis. The receptor for advanced glycation endproducts (RAGE) is a membrane protein，and AGE-RAGE is associated with bone degradation. Oxidative stress fosters AGE formation，hampering enzymatic crosslinking, compromising collagen integrity，and reducing bone resilience. Nonetheless，the relationship between AGEs and their receptor RAGE in osteoporosis remains enigmatic. This review aims to unveil the impact of the AGE-RAGE signaling pathway mediated by glycation end products in osteoporotic cellular biology. |
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