| Lactic acid is a product of glycolysis produced by cells under anaerobic conditions. For a long time it is considered as a metabolic waste product of the body. Recent studies have shown that lactate plays an important role in various aspects of human metabolism, immune regulation, energy supply, epigenetic modification, and affects bone metabolism. This has broken our traditional perception of lactate. In this paper, we review the related studies on lactic acid and histone lactylation and bone metabolism, describe the effects of histone lactylation, lactate-related products (MCT and LDH), and lactate on bone metabolism through the HIF-1 pathway and the bone immune pathway, and explore the mechanisms, in the hope of providing a reference for the later studies on the effects of lactic acid on bone metabolism. |