| Bone homeostasis involves bone formation and bone resorption mediated by osteoblasts and osteoclasts, respectively. The integrity of bone tissue is dependent on the dynamic balance between the two. MOTS-c, as a novel mitochondria-derived peptide (MDPs), is an important mediator of mitochondrial-cellular information exchange, and plays an important role in the maintenance of energy conversion and metabolic homeostasis of the body. It plays an important role in the maintenance of energy conversion and metabolic homeostasis. Studies have shown that MOTS-c regulates the activity of osteoblasts and osteoclasts, thus affecting bone homeostasis. Exercise, as an exogenous stimulus, is involved in the development of various diseases by affecting MOTS-c expression in a cell-environment context. This suggests that exercise serves as a bridge between macroscopic and microscopic stimuli and plays an important role in influencing disease development. However, the specific mechanism by which exercise regulates MOTS-c expression in bone tissue is unknown, and the detailed mechanism between MOTS-c and bone homeostasis has rarely been explored. Based on this, this paper comprehensively reviews the distribution and function of MOTS-c, summarizes the detailed mechanisms by which it affects bone homeostasis, and systematically discusses the potential association between MOTS-c, exercise and bone homeostasis, which provides a new perspective for the prevention and treatment of metabolic bone diseases. |