中国骨质疏松杂志

骨碎补及其活性成分防治骨质疏松症的作用机制

The mechanism of rhizoma drynariae and its active components in the prevention and treatment of osteoporosis

DOI：10.3969/j.issn.1006-7108.2024.10.024

中文关键词: 骨质疏松症骨碎补骨碎补总黄酮柚皮苷成骨细胞破骨细胞间充质干细胞。

英文关键词:osteoporosis rhizoma drynariae total flavonoids of rhizoma drynariae naringin osteoblast osteoclast mesenchymal stem cell

基金项目:深圳市中老年群体骨健康状况流行病学研究（2022110）

作者	单位
刘博1 丁龙龙1 陈志健1 张桂鑫2 王博2 龚春柱1* 张洪健3	1.广州中医药大学，广东广州 510405 2.广州中医药大学附属深圳平乐骨伤科医院，广东深圳 518010 3.河南中医药大学，河南郑州 450046

摘要点击次数: 118

全文下载次数: 0

中文摘要:

骨碎补是补肾强骨的经典药材，药理学研究显示其主要活性成分为黄酮类和二氢黄酮类柚皮苷，其在抗骨质疏松、修复骨缺损等方面发挥着积极作用。细胞分子生物学研究提示骨碎补对成骨细胞、破骨细胞和间充质干细胞具有多通路、多因子调节作用，如Wnt/β-catenin、MAPK、OPG/RANKL/RANK、Notch、BMP-Smads、PI3K/Akt等信号通路和TNF-α、白介素-1(IL-1)、白介素-6(IL-6)、雌激素及其受体、组织蛋白酶K(CTSK)等细胞因子。全文重点综述了中药骨碎补及其提取物防治骨质疏松的信号通路和细胞因子研究进展，旨在为骨碎补的药理药效研究及临床应用提供参考。

英文摘要:

Rhizoma drynariae is a classic medicine for tonifying kidney and strengthening bone. Pharmacological studies show that its main active components are flavonoids and dihydroflavonoid naringin, which play an active role in anti-osteoporosis and repairing bone defects. Cellular and molecular biological studies suggest that drynaria regulates osteoblasts, osteoclasts, and mesenchymal stem cells through multiple pathways and multiple factors, such as Wnt/β-catenin, MAPK, OPG/RANKL/RANK, Notch, BMP-Smads, PI3K/Akt, and cytokines such as TNF-α, interleukin-1 (IL-1), interleukin-6 (IL-6), and estrogen and its receptor, Cathepsin K (CTSK). This paper focuses on the research progress of signal pathways and cytokines of rhizoma drynariae and its extracts in the prevention and treatment of osteoporosis, in order to provide reference for the pharmacological and pharmacological research and clinical application of drynaria.

查看全文查看/发表评论下载PDF阅读器

关闭