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| 2型糖尿病患者胰岛素抵抗代谢评分与骨密度的相关性 |
| Correlation analysis of metabolic score of insulin resistance and osteoporosis in type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1006-7108.2024.11.007 |
| 中文关键词: 2型糖尿病 骨密度 骨质疏松 胰岛素抵抗代谢评分 |
| 英文关键词:type 2 diabetes mellitus bone mineral density osteoporosis metabolic score of insulin resistance |
| 基金项目:国家自然科学基金(81760165)；广西自然科学基金(2023GXNSFAA026148) |
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| 中文摘要: |
| 目的 探讨2型糖尿病（type 2 diabetes mellitus，T2DM）患者胰岛素抵抗代谢评分(metabolic score for insulin resistance，METS-IR)与骨密度(bone mineral density，BMD)是否具有相关性。方法 纳入370例T2DM患者，根据骨密度分为骨质疏松组和非骨质疏松组。收集患者的一般资料和骨密度值，计算METS-IR。分析METS-IR与骨密度之间的关系。结果 男性T2DM患者中合并骨质疏松症的METS-IR显著低于非骨质疏松组（P＜0.05）。Spearman相关分析显示METS-IR与髋部整体、腰椎整体和股骨颈BMD呈正相关(P＜0.001)。在校正潜在因素后，二元Logistic回归分析结果显示，METS-IR是男性和女性T2DM患者骨密度的保护因素(OR=0.916，95%CI：0.870～0.964，P=0.001；OR=0.945，95%CI：0.898～0.995，P=0.033)。结论 在T2DM 患者中，METS-IR与股骨颈、髋部整体和腰椎BMD相关。METS-IR可能是骨密度的保护因素。 |
| 英文摘要: |
| Objective To examine the association between metabolic score of insulin resistance (METS-IR) and bone mineral density (BMD)，as well as osteoporosis in patients with type 2 diabetes mellitus(T2DM). Methods A total of 370 patients with type 2 diabetes mellitus were divided into osteoporosis group and non-osteoporosis group. General data and bone mineral density of patients were collected and METS-IR was calculated. The relationship between METS-IR and bone mineral density was analyzed. Results The level of METS-IRin male T2DM patients with osteoporosis was notably lower than that in the non-osteoporosis group (P<0.05). Analysis using Spearman correlation revealed a significant positive relationship between METS-IR and total hip bone mineral density (BMD)，as well as lumbar spine and femoral neck BMD (all P< 0.001).Upon controlling for potential confounders，logistic regression analysis demonstrated that male and female patients with with T2DM，METS-IR levels served as a protective factor against osteoporosis (OR=0.916，95% CI：0.870-0.964，P=0.001) and (OR=0.945，95% CI: 0.898-0.995，P=0.033)，respectively. Conclusion In patients with T2DM，the METS-IR is closely associated with BMD in the femoral neck，hip，and lumbar spine. METS-IR may serve as a protective factor for bone density, indicating potential clinical reference value. |
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