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| 中医药治疗绝经后骨质疏松临床疗效研究 |
| Research progress in the clinical efficacy of traditional Chinese medicine on the treatment of postmenopausal osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2024.11.017 |
| 中文关键词: 中医药 绝经期后骨质疏松症 骨代谢 机制 |
| 英文关键词:traditional Chinese medicine postmenopausal osteoporosis bone metabolism mechanism |
| 基金项目:国家自然科学基金项目（82305264）；广州市青年科技人才托举项目（QT-2023-022）；市校（院）联合资助（登峰医院）基础研究项目（20220102030）；基础与应用基础研究专题（青年博士“启航”项目）（2024A04J4331）；广州中医药大学第一附属医院中青年骨干人才培育项目-青优人才（2023QY13） |
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| 中文摘要: |
| 绝经后骨质疏松症（postmenopausal osteoporosis, PMOP）是因雌激素分泌减少、骨代谢与骨吸收失衡引起的代谢性疾病，严重影响中老年妇女的正常生活。但由于PMOP发病复杂，其确切机制至今仍未阐明。如何治疗PMOP是当今备受关注的社会问题。大量研究表明，中医药在治疗PMOP时可提高患者骨密度及雌激素水平，并缓解患者疼痛症状。本文结合近五年中医药治疗PMOP的相关中外文献进行回顾，从患者疼痛状况、骨密度、骨代谢指标等评估中医药治疗PMOP的临床效果，并从Runx2与BMP-2、RANKL/RANK/OPG调节轴、MAPK和NF-κβ途径、Wnt/β–catenin等信号通路及生物调节因子入手，进一步探究和概括中医药治疗PMOP的起效机制。 |
| 英文摘要: |
| Postmenopausal osteoporosis (PMOP) is a metabolic disease resulting from decreased estrogen secretion and an imbalance in bone metabolism and absorption, significantly impacting the quality of life of middle-aged and elderly women. However, due to the intricate pathogenesis of PMOP, the precise mechanism remains elusive. The treatment of PMOP has become a matter of great concern in society. Numerous studies have shown that traditional Chinese medicine has achieved good therapeutic effects on improving bone mineral density and estrogen levels in patients with PMOP, as well as on alleviating pain symptoms. This article reviews the relevant Chinese and foreign literature in the treatment of PMOP with traditional Chinese medicine in the past 5 years, weighing the clinical efficacy of traditional Chinese medicine in treating PMOP from multiple aspects such as patient pain status, bone mineral density, and bone metabolism indicators. The mechanism of traditional Chinese medicine in the treatment of PMOP is further explored and summarized from the aspects of RUNX2, BMP-2, RANKL/RANK/OPG regulatory axis, MAPK, NF-κB pathway, and Wnt/β. |
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