| As a gasotransmitter, the role of hydrogen sulfide (H2S) in preventing and treating osteoporosis has been confirmed in recent years, and its pathophysiological mechanism is gradually elucidated. H2S counteracts oxidative stress and inflammatory reactions, promotes angiogenesis, regulates intestinal flora and calcium-phosphorus metabolism, thus enhancing bone formation and inhibiting bone resorption, further preventing and treating various types of osteoporosis, such as postmenopausal osteoporosis and, glucocorticoid, or homocysteine-induced osteoporosis. This article summarizes the existing research to provide new insights for further understanding the pathogenesis and treatment of osteoporosis. |