| Osteoporosis is a systemic bone disorder characterized by the loss of bone mass and the destruction of bone tissue microstructure, significantly impacting patients' quality of life. Mitochondria and their components play crucial roles in intercellular communication under both physiological and pathological conditions. Dysfunctional mitochondria-derived intercellular communication can adversely affect the activity of osteoblasts and osteoclasts, leading to bone mass loss, disruption of bone microstructure, and ultimately, the development of osteoporosis. This paper provides an overview of mitochondria-derived intercellular communication, highlighting its central role in cellular communication and various physiological and pathological processes. Furthermore, it explores the link between mitochondria-derived intercellular communication and osteoporosis, particularly focusing on bone marrow mesenchymal stem cells, osteoblasts, osteocyte, and osteoclasts. The study reveals the significant involvement of mitochondria-derived intercellular communication in osteoporosis, shedding light on potential new therapeutic targets and offering insights for the treatment of this condition. |