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| 从“肝肾-线粒体”关联探讨铁死亡与骨关节炎相关性 |
| Exploration of the relationship between ferroptosis and osteoarthritis from the liver-kidney-mitochondria association |
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| DOI：10.3969/j.issn.1006-7108.2024.12.019 |
| 中文关键词: 铁死亡 线粒体 中医中药 骨关节炎 |
| 英文关键词:ferroptosis mitochondria traditional Chinese medicine osteoarthritis |
| 基金项目:国家自然科学基金项目（81473672）；安徽省名中医工作室建设项目[中发展(2022)5号]；安徽省中医优势专科[皖中医药服务秘(2022)34号]；安徽省教育厅研究生创新创业实践项目（ahzyydx-tb93） |
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| 中文摘要: |
| 骨关节炎发病内核在于机体气血津液输布异常，外邪阻滞机体经络导致病理产物蓄积体内，造成机体代谢失常。本文基于“肝肾-线粒体”关联理论阐述线粒体功能失衡诱发铁死亡从而干预骨关节炎的发生及发展过程，认为肝肾亏虚，气滞血瘀与线粒体、铁死亡促进骨关节炎氧化应激诱导的损伤及软骨细胞凋亡有共通之处，并以肝肾为先天之本等理论及线粒体为真核生物细胞的"发源地"等生物学理论作为导向，丰富骨关节炎病机理论，从而为中医药防治骨关节炎进展提供辨治思路。 |
| 英文摘要: |
| The core of osteoarthritis lies in the abnormal distribution of qi, blood and fluid. The blockade of the body's meridians by external evils leads to the accumulation of pathological products in the body, resulting in metabolic disorders of the body and the pathological outcome of osteoarthritis. Based on the liver-kidney-mitochondria association theory, this paper expounds the mitochondrial dysfunction induced ferroptosis to intervene in the occurrence and development of osteoarthritis, and argues that liver and kidney deficiency, qi stagnation, and blood stasis have something in common with mitochondria and ferroptosis to promote osteoarthritis oxidative stress-induced damage and chondrocyte apoptosis. |
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