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| 从骨微结构角度探寻骨质疏松症的病情演变 |
| To explore the progress of diagnosis and treatment of osteoporosis from the perspective of bone microstructure |
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| DOI：10.3969/j.issn.1006-7108.2024.12.021 |
| 中文关键词: 骨质疏松症 骨皮质 骨小梁 |
| 英文关键词:osteoporosis cortical bone trabecular bone |
| 基金项目:江苏省中医药管理局科技项目(MS2021023)；南京中医药大学自然科学基金项目（XZR2023011)；南京市中医药传承创新发展示范试点资助项目(NJCC-ZJ-202349) |
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| 中文摘要: |
| 骨质疏松防治是目前研究热点，现有治疗更多关注成骨和破骨细胞功能，而骨微结构损伤会导致骨强度降低，在骨质疏松发病中同样也起着重要作用。在骨微观架构中，骨小梁是承受复合力学的主要结构，而骨皮质主要维持力学改变的适应能力，两者在骨质疏松进程中表现不一，对常规抗骨质疏松治疗的药物反应也有所差异。该文将从骨微结构损伤方面探寻骨质疏松症的病情演变。 |
| 英文摘要: |
| The prevention and treatment of osteoporosis is currently a research hotspot, and the existing treatments pay more attention to the function ofosteoblasts and osteoclasts，while the damage of bone microstructure will lead to the reduction of bone strength，which also plays an important role in the pathogenesis of osteoporosis. In the microstructure of bone，trabecula is the main structure to withstand complex mechanics，while cortical bone mainly maintains the ability to adapt to mechanical changes. The two have different performance in the process of osteoporosis and have different drug responses to conventional anti-osteoporosis therapy. In this paper，we will explore the progress of diagnosis and treatment of osteoporosis from the perspective of bone microstructure. |
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