| Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovitis, bone destruction, and pannus formation. Among them, abnormal glucose metabolism significantly promotes the pathogenic behavior of RA. Especially, hexokinase 2 (HK2) promotes inflammation, inhibits apoptosis, promotes autophagy, induces mitochondrial oxidative stress by mediating glycolysis metabolism, and plays a key role in immune regulation, bone destruction, and adaptation to hypoxia. Therefore, the abnormal regulation of HK2 may be involved in the molecular mechanism of RA and may become a very attractive alternative metabolic target for RA therapy. Based on this, this paper systematically reviews the latest literature of HK2 in the pathogenesis of RA, in order to provide new reference basis for the pathogenesis and treatment of RA. |