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| 中医药基于铁死亡防治骨性关节炎研究进展 |
| Research progress in TCM prevention and treatment of osteoarthritis based on iron death theory |
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| DOI：10.3969/j.issn.1006-7108.2025.01.020 |
| 中文关键词: 铁死亡 骨性关节炎 铁蓄积 脂质过氧化 炎症因子 |
| 英文关键词:iron death osteoarthritis iron accumulation lipid peroxidation inflammatory factor |
| 基金项目:甘肃省临床医学研究中心建设项目（I8JR2FA009）；甘肃省自然科学基金（22JR11RA197） |
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| 中文摘要: |
| 骨性关节炎(osteoarthritis，OA)是一种多见于中老年人群的退行性骨关节疾病，其病理主要是软骨损伤、炎症反应，表现为关节疼痛、肿胀、活动受限等，严重可导致患者畸形。OA的发病与炎症、软骨细胞的代谢密切相关，铁死亡参与炎症因子、软骨细胞的代谢过程，通过下调铁沉积、脂质过氧化来延缓炎症反应与软骨损伤进而防治OA。研究发现，中药可以通过调节铁死亡抑制OA发病机制进而达到治疗OA的目的。笔者简要叙述铁死亡的作用机制与OA的关系，对中药基于铁死亡治疗OA的作用作一综述，为未来研究中医药治疗OA提供新的治疗策略。 |
| 英文摘要: |
| Osteoarthritis (OA) is a degenerative bone and joint disease commonly seen in middle-aged and elderly people. Its pathology is mainly cartilage injury and inflammation, manifested as joint pain, swelling, and limited activity, etc., which can lead to deformity in patients in severe cases. The pathogenesis of OA is closely related to inflammation and the metabolism of chondrocytes. Iron death is involved in the metabolic process of inflammatory factors and chondrocytes. By down-regulating iron deposition and lipid peroxidation, inflammation and cartilage damage may be delayed to prevent OA. It has been found that traditional Chinese medicine could inhibit the pathogenesis of OA by regulating iron death and thus achieve the purpose of OA treatment. This article briefly describes the mechanism of iron death and its relationship to OA, and briefly reviews the effect of traditional Chinese medicine on OA based on iron death. It provides a new therapeutic strategy for the future study of OA treatment with traditional Chinese medicine. |
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