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| db/db小鼠2型糖尿病骨质疏松模型的研究 |
| Study on osteoporosis model of type 2 diabetes in db/db mice |
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| DOI：10.3969/j.issn.1006-7108.2025.01.023 |
| 中文关键词: db/db小鼠 2型糖尿病性骨质疏松症 动物模型 模型应用 |
| 英文关键词:db/db mice type 2 diabetic osteoporosis animal model model application |
| 基金项目:国家自然科学基金面上项目（82174260）；辽宁省科学技术厅联合基金博士科研启动项目（2023-BSBA-224） |
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| 中文摘要: |
| db/db小鼠是广泛应用于2型糖尿病及其并发症实验研究的动物模型，对评价新药药效及阐明病理生理学机制的研究具有重要的意义。本文通过检索中英文数据库梳理db/db小鼠的遗传背景和病理特征，并收集整理了以db/db小鼠为2型糖尿病性骨质疏松症模型开展的现代药物、中药及相关临床应用的基础研究，以期为今后本病的实验研究提供可靠的证据。 |
| 英文摘要: |
| db/db mice are widely used in the experimental study of type 2 diabetes and
its complications , which is of great significance to evaluate the efficacy of new drugs
and elucidate the pathophysiological mechanism of type 2 diabetes. In this paper, the
genetic background and pathological characteristics of db/db mice were summarized by
searching Chinese and English databases, and the basic research on modern medicine,
traditional Chinese medicine and related clinical application of db/db mice as type 2
diabetic osteoporosis model was collected, in order to provide reliable evidence for future experimental research on the disease. |
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