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| 胆汁酸代谢在绝经后骨质疏松症中作用：病理机制与干预 |
| The role of bile acid metabolism in postmenopausal osteoporosis: pathological mechanism and intervention |
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| DOI：10.3969/j.issn.1006-7108.2025.03.017 |
| 中文关键词: 绝经后骨质疏松症 胆汁酸代谢 胆汁酸受体 骨平衡 药物 |
| 英文关键词:postmenopausal osteoporosis bile acid metabolism bile acid receptor bone balance drugs |
| 基金项目:甘肃省科技重点研发计划项目（23YFFA0068）；甘肃省教育厅高等学校科研项目（2023A-080）；甘肃中医药大学成果转化培育项目（2023CGZH-21）；甘肃省中医药管理局项目（GZKP-2023-19）；甘肃中医药大学研究生创新创业基金资助项目 |
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| 中文摘要: |
| 绝经后骨质疏松症（postmenopausal osteoporosis，PMOP）是由于绝经后雌激素水平下降导致骨量减少和骨微结构破坏的全身代谢性骨病。最近的研究发现，胆汁酸(bile acids，BAs)在肝脏中合成并被肠道微生物群修饰，进而入血参与机体各脏器代谢，对于重塑骨平衡至关重要。本文就BAs调控骨形成和骨吸收，并参与绝经后骨质疏松疾病进展的研究及通过药物干预该途径改善PMOP的相关研究进行综述。重点围绕胆汁酸代谢途径，揭示PMOP的病理机制及干预途径，以期为治疗PMOP提供新的思路和靶点。 |
| 英文摘要: |
| Postmenopausal osteoporosis (PMOP) is a systemic metabolic bone disease that results in decreased bone mass and destruction of bone microarchitecture due to decreased levels of oestrogen after menopause. Recent studies have found that bile acids (BAs), which are synthesised in the liver and modified by the gut microbiota, and then enter the bloodstream to participate in the metabolism of various organs of the body, are essential for remodelling bone homeostasis. This paper provides a review on the study of BAs regulating bone formation and bone resorption and participating in the progression of postmenopausal osteoporosis disease and the related study of improving PMOP by pharmacological intervention in this pathway. Focusing on the bile acid metabolic pathway, it reveals the pathological mechanisms and intervention pathways of PMOP, with a view to providing new ideas and targets for the treatment of PMOP. |
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