| Osteoporosis (OP) is a degenerative bone disease characterized by decreased bone mass and deterioration of bone tissue microarchitecture, which increases the fragility of bones and the risk of fractures. Currently, the drugs used in the clinical treatment of OP are mainly divided into two types: bone resorption inhibitors and bone formation enhancers. Although they have certain efficacy, most anti-OP drugs are not delivered to the bone tissues in a targeted manner, and at the same time, they can produce certain toxic side effects. In recent years, nanoparticle bone-targeted therapy, which is characterized by large drug loading capacity, strong targeting, easy modification and taught biocompatibility, can effectively overcome the shortcomings of traditional therapies and has been widely used in the treatment of OP. For this reason, this paper reviews the progress of bone-targeted nanoparticle-based treatment of OP in recent years to provide a theoretical basis for exploring the therapeutic strategy of nanoparticle-based intervention in OP. |