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| STAT3信号通路调控骨重塑研究进展 |
| Research progress on the regulation of bone remodeling by STAT3 signaling pathway |
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| DOI：10.3969/j.issn.1006-7108.2025.03.019 |
| 中文关键词: 骨重塑 STAT3信号通路 研究进展 |
| 英文关键词:bone remodeling STAT3 signaling pathway research progress |
| 基金项目:国家自然科学基金优秀青年基金项目（82222076）；国家自然科学基金面上项目（82074463）；北京中医药大学东直门医院临床研究和成果转化能力提升试点项目（DZMG-XZYY-23010） |
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| 中文摘要: |
| 骨质疏松性骨折患者骨代谢紊乱、骨密度降低、骨质脆弱，同时老年化导致的血管功能减退进一步延迟了骨折后血管生成过程。因此，与一般骨折相比，骨质疏松性骨折愈合慢、愈合难甚至不愈合。骨折后骨重塑涉及骨组织与骨血管再生过程。研究表明，信号传导与活化转录因子3（signal transducers and activators of transcription 3，STAT3）信号通路能够通过影响细胞分化、促进血管生成、参与炎症反应等病理生理过程，调控骨代谢促进骨折部位骨骼形成，还能促进骨微环境血管生成以改善骨折部位血液营养供应，从而影响骨重塑进程。本文通过总结近年相关文献，对STAT3信号通路调控骨重塑研究进行综述。 |
| 英文摘要: |
| In patients with osteoporotic fractures, there is a disorder of bone metabolism, decreased bone density, and fragile bone. At the same time, the decline of vascular function caused by aging further delays the process of angiogenesis after fractures. Therefore, compared with general fractures, osteoporotic fractures heal more slowly, heal more difficult or even do not heal. Post-fracture bone remodeling involves bone tissue and bone vascular regeneration. Studies have shown that signal transducers and activators of transcription 3 (STAT3) signaling pathways can affect cell differentiation, promote angiogenesis, and participate in pathophysiological processes such as inflammatory responses. It can also promote angiogenesis in the bone microenvironment to improve blood nutrient supply at the fracture site, thereby affecting the process of bone remodeling. This article summarizes recent literature on the regulation of bone remodeling by the STAT3 signaling pathway. |
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