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| 非高密度与高密度脂蛋白胆固醇比值与骨质疏松的关联 |
| Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2025.05.003 |
| 中文关键词: 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值 脂质比 骨质疏松症 国家健康与营养检查调查 横断面研究 骨健康 |
| 英文关键词:NHHR lipid ratio osteoporosis NHANES cross-sectional study bone health |
| 基金项目:广州市荔湾区科技计划项目（20240612）；国家自然科学基金（82374482；82274551） |
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| 中文摘要: |
| 目的 近期研究表明，非高密度脂蛋白胆固醇（non-HDL-C）与高密度脂蛋白胆固醇（HDL-C）比值（NHHR）已成为多种健康结果的潜在标志，但其与骨质疏松症的关联尚未得到充分研究。本研究旨在探讨NHHR与中老年人群骨质疏松症风险之间的关系。方法 本研究利用2005年-2010年NHANES（国家健康与营养检查调查）数据，分析50岁及以上人群中NHHR与骨质疏松症的关系。采用的分析方法包括多变量逻辑回归、限制性立方样条（RCS）分析以及对相关人口学和临床变量调整的亚组分析。结果 共纳入5 548名参与者，其中313名被诊断为骨质疏松症。分析结果表明，NHHR与骨质疏松症呈显著负相关。与NHHR最低四分位组相比，NHHR最高四分位组的骨质疏松症风险显著降低，调整后[OR: 0.63 (95% CI: 0.44~0.90, 趋势P值=0.004)]。RCS分析证实，NHHR与骨质疏松症之间存在非线性关联（总P值<0.001，非线性P值=0.008）。亚组分析显示，各个人口学和临床亚组中的结果一致。结论 本研究发现，较高的NHHR水平与50岁及以上人群中较低的骨质疏松症风险显著相关。NHHR可能是评估该人群骨质疏松症风险的可靠标志。应开展进一步的研究探讨这一潜在关联。 |
| 英文摘要: |
| Objective Recent studies have shown that the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) has become a potential marker for various health outcomes. However, its association with osteoporosis has not been fully explored. This study aims to investigate the relationship between NHHR and the risk of osteoporosis in the elderly. Methods This study used data from the 2005-2010 National Health and Nutrition Examination Survey (NHANES) to analyze the association between NHHR and osteoporosis in individuals aged 50 and above. The analytical methods included multivariable logistic regression, restricted cubic spline (RCS) analysis, and subgroup analyses adjusting for relevant demographic and clinical variables. Results A total of 5548 participants were included, of whom 313 were diagnosed with osteoporosis. The analysis showed a significant inverse correlation between NHHR and osteoporosis. Compared to the lowest quartile of NHHR, the highest quartile had a significantly lower risk of osteoporosis, even after adjustment [OR: 0.63 (95% CI:0.44-0.90, trend P=0.004)]. The RCS analysis confirmed a nonlinear relationship between NHHR and osteoporosis (overall P<0.001, nonlinearity P=0.008). Subgroup analyses showed consistent results across various demographic and clinical subgroups. Conclusion This study found that higher NHHR levels are significantly associated with a lower risk of osteoporosis in individuals aged 50 and above. NHHR may be a useful marker for assessing osteoporosis risk in this population. Further research should explore this potential association. |
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