|
| β-CTX、T-P1NP及其比值与老年女性骨质疏松相关性 |
| The correlation between β-CTX, T-P1NP and their ratios and osteoporosis in elderly female patients |
| |
| DOI：10.3969/j.issn.1006-7108.2025.05.004 |
| 中文关键词: 骨质疏松 β胶原特殊序列 总1型胶原氨基端延长肽 骨折风险 |
| 英文关键词:osteoporosis β collagen special sequence total type 1 collagen fracture risk |
| 基金项目: |
|
| 摘要点击次数: 1103 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 分析在老年女性骨质疏松患者中，β胶原特殊序列（β-CTX）、总1型胶原氨基端延长肽（T-P1NP）水平及两者比值与骨质疏松的相关性。方法 选取中国航天科工集团七三一医院2023年10月至2024年2月收治的老年女性骨质疏松患者100例（骨质疏松组），另选同期体检且无骨质疏松者50例（对照组，女性）及骨量减少组50例（女性），采集三组血液样本后采用化学发光法检测血清β-CTX、T-P1NP水平，计算两者比值，比较三组血清各指标差异。同时采用骨折风险评价工具（FRAX）评估骨质疏松组患者骨折发生风险，比较高危骨折组及非高危组患者相关指标差异。并采用Spearman相关性分析法研究血清β-CTX、T-P1NP及其比值与骨质疏松患者骨密度、骨折风险发生的相关性。结果 骨质疏松组血清β-CTX、T-P1NP水平及β-CTX/T-P1NP值高于骨量减少组、对照组，骨密度低于骨量减少组、对照组，骨量减少组患者血清β-CTX、T-P1NP水平及β-CTX/T-P1NP值高于对照组，骨密度低于对照组（P＜0.05）。高危骨折组血清β-CTX、T-P1NP水平及β-CTX/T-P1NP值均高于非高危组，骨密度低于非高危组（P＜0.05）。血清β-CTX、T-P1NP水平及β-CTX/T-P1NP值与骨密度呈负相关性（P＜0.05）；血清β-CTX、T-P1NP、β-CTX/T-P1NP与骨质疏松性骨折风险呈正相关，骨密度与骨质疏松性骨折发生风险呈负相关（P＜0.05）。结论 老年女性骨质疏松患者血清β-CTX、T-P1NP水平及β-CTX/T-P1NP值明显升高，骨密度降低，血清β-CTX、T-P1NP水平及β-CTX/T-P1NP值对诊断骨质疏松及判断骨折风险有一定作用。 |
| 英文摘要: |
| Objective To analyze the correlation between the levels and ratio of β- collagen specific sequence (β- CTX), total type 1 collagen N-terminal extended peptide (T-P1NP), and osteoporosis in elderly female patients. Methods One hundred elderly female patients admitted to China Aerospace Science and Industry Corporation (CASIC) 731 Hospital from October 2023 to February 2024 were selected in the osteoporosis group, and 50 cases with no osteoporosis during the same period of physical examination were selected in the control group and 50 cases in the bone loss group. The levels of serum β-CTX and T-P1NP were detected with chemiluminescence, and the ratio of the two was calculated. Then the differences of the indicators in the three groups were compared and the correlation with osteoporosis was analyzed. The fracture risk assessment tool (FRAX) was used to assess the risk of fracture occurrence in patients in the osteoporosis group.The differences in the relevant indicators between patients in the high-risk fracture group and those in the non-high-risk group were compared. The spearman correlation analysis was used to study its correlation with bone mineral density and fracture risk occurrence in osteoporosis patients. Results In the osteoporosis group, serum β- CTX and T-P1NP levels and their ratio were higher than those in the bone loss group and the control group, while bone mineral density was lower than that in the bone loss group and control group. In the bone loss group, β-CTX and T-P1NP levels and their ratio were higher than those in the control group, while bone mineral density was lower than that in the control group (P<0.05). Serum β-CTX and T-P1NP levels and β-CTX/T-P1NP values were higher in the risk group than in the non-risk group, and bone mineral density was lower than in the non-risk group (P<0.05). The levels of serum β-CTX, T-P1NP, and β-CTX/T-P1NP were negatively correlated with bone mineral density (P<0.05). Serum β-CTX, T-P1NP, β-CTX/T-P1NP are positively correlated with the risk of osteoporotic fractures, while bone mineral density was negatively correlated with the risk of osteoporotic fractures (P <0.05). Conclusion Elderly women with osteoporosis have significantly higher serum β-CTX, T-P1NP levels and β-CTX/T-P1NP value and lower bone mineral density. This is useful for diagnosing osteoporosis and determining fracture risk. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|