|
| NFATc1在绝经后骨质疏松症中的作用及中药干预进展 |
| Role of NFATc1 in postmenopausal osteoporosis and progress of Chinese medicine intervention |
| |
| DOI：10.3969/j.issn.1006-7108.2025.05.021 |
| 中文关键词: 绝经后骨质疏松症 NFATc1 破骨细胞 骨吸收 中医中药 |
| 英文关键词:postmenopausal osteoporosis NFATc1 osteoclast bone resorption medicinal herb |
| 基金项目:甘肃省名中医传承工作室建设项目；甘肃省联合科研基金（23JRRA1519） |
|
| 摘要点击次数: 1577 |
| 全文下载次数: 0 |
| 中文摘要: |
| 绝经后骨质疏松症（postmenopausal osteoporosis，PMOP）是以骨质流失、骨量减少、骨微观结构破坏为特征的骨科疾病，严重影响着绝经后女性的身心健康。活化T细胞核因子C1（nuclear factor of activated T-cells, cytoplasmic 1，NFATc1）是调控破骨细胞分化和骨吸收的特异性基因，是维持骨稳态的关键因子。研究发现，多种中药单体及复方可通过抑制NFATc1上下游基因和信号通路，阻碍其核转位，抑制破骨细胞分化及骨吸收，达到干预PMOP的作用，成为该病的潜在治疗靶点。因此，笔者通过阐释NFATc1在PMOP中的作用，并总结中药单体化合物及中药复方干预PMOP的最新研究进展，为其发病机制及药物治疗提供新思路，为临床运用中医药防治PMOP提供理论依据。 |
| 英文摘要: |
| Postmenopausal osteoporosis (PMOP) is an orthopedic disease characterized by bone loss, decreased bone mass and destruction of bone microstructure, which seriously affects the physical and mental health of postmenopausal women. nuclear factor of activated T-cells, cytoplasmic 1, NFATc1 (NFATC1) is a specific gene regulating osteoclast differentiation and bone resorption, and is a key factor in maintaining bone homeostasis. Studies have shown that a variety of TCM monomers and compounds can interfere with PMOP by inhibiting the upstream and downstream genes and signaling pathways of NFATc1, blocking its nuclear translocation, inhibiting osteoclast differentiation and bone resorption, and becoming potential therapeutic targets for the disease. Therefore, this paper aims to elucidate the role of NFATc1 in PMOP, and summarize the latest research progress of TCM monomer compounds and TCM compound intervention in PMOP, so as to provide new ideas for its pathogenesis and drug treatment, and provide theoretical basis for clinical application of traditional Chinese medicine to prevent and treat PMOP. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |