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| 骨免疫学：T细胞在骨代谢调控中的双向作用 |
| Bone immunology: bidirectional role of T cells in the regulation of bone metabolism |
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| DOI：10.3969/j.issn.1006-7108.2025.06.017 |
| 中文关键词: 骨免疫 T细胞 骨代谢 成骨细胞 破骨细胞 |
| 英文关键词:bone immunity T cells bone metabolism osteoblast osteoclast |
| 基金项目:甘肃省高等学校产业支撑计划项目(2022CYZC-52); 甘肃中医药大学中医学一级学科“岐黄英才”博导基金项目(2022-01); 2023年度甘肃中医药大学成果转化培育项目(2023CGZH-1) |
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| 中文摘要: |
| 骨免疫学强调骨骼和免疫细胞之间的双向通讯。骨代谢稳态是骨形成与骨吸收动态平衡的关键，对骨骼的发育及健康有着重要作用。T细胞是免疫系统的主要成员，通过极化为不同亚群，产生一系列细胞因子，参与调节骨稳态。骨骼和免疫系统通过共享多种调节分子和组织微环境而相互影响。本文基于骨免疫学理论对T细胞分类及功能和T细胞对骨代谢作用的相关性进行综述，旨在为代谢性骨病的防治研究提供新思路。 |
| 英文摘要: |
| Bone immunology emphasizes two-way communication between bone and immune cells. Bone metabolic homeostasis is the key to the dynamic balance between bone formation and bone resorption and plays an important role in bone development and health. T cells are major members of the immune system. By polarizing into different subpopulations, T cells produce a range of cytokines that are involved in the regulation of bone homeostasis. Bone and the immune system interact by sharing multiple regulatory molecules and tissue microenvironments. Based on the theory of bone immunology, the classification and function of T cells and the correlation between T cells and bone metabolism are reviewed in this paper, aiming to provide new ideas for the prevention and treatment of metabolic bone diseases. |
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