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| 地塞米松调控成骨细胞作用机制及中药干预研究进展 |
| Regulation of the mechanism of the osteoblast by dexamethasone and progress in the intervention of TCM |
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| DOI：10.3969/j.issn.1006-7108.2025.06.018 |
| 中文关键词: 地塞米松 成骨细胞 骨形成 中药单体 信号通路 |
| 英文关键词:dexamethasone osteoblasts bone formation TCM monomer signaling pathway |
| 基金项目:甘肃省中医院横向课题（20180401);兰州市科技计划项目(2023-2-20);兰州市科技计划项目(2023-ZD-49) |
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| 中文摘要: |
| 成骨细胞骨形成功能障碍是临床常见老年骨代谢疾病的病理基础。地塞米松不仅广泛用于治疗炎症及自身免疫性疾病，而且在成骨细胞增殖分化等过程中发挥重要作用。最近研究表明，地塞米松通过调节PI3K/AKT、Wnt/β-catenin、Chk2/p53、SGK1/FOXO3a、IGF-1等信号通路来影响成骨分化功能。本文通过对地塞米松调控成骨细胞作用机制及其中药干预的研究进展作一综述，以期为成骨细胞相关研究提供新的思路，并为地塞米松诱导的成骨细胞功能障碍导致的骨质疏松症临床治疗提供新研究方向。 |
| 英文摘要: |
| The dysfunction of osteoblastic bone formation is the pathological basis of common clinical bone metabolic diseases in the elderly. Dexamethasone is not only widely used in the treatment of inflammation and autoimmune diseases, but also plays an important role in the process of osteoblast proliferation and differentiation. Recent studies have shown that dexamethasone affects osteogenic differentiation function by regulating PI3K/AKT, Wnt/β-catenin, Chk2/p53, SGK1/FOXO3a, and IGF-1, etc. This paper reviews the mechanism of the regulation of osteoblasts and the progress of TCM intervention, in order to provide new ideas for the study of osteoblasts and to provide new research directions for the clinical treatment of osteoporosis due to dexamethasone-induced osteoblast dysfunction. |
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