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| circRNA-miRNA网络调控骨质疏松研究进展 |
| Advances in the circRNA-miRNA network regulation in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2025.06.020 |
| 中文关键词: 骨质疏松症 circRNA-miRNA网络 非编码RNA 综述 |
| 英文关键词:osteoporosis circRNA-miRNA network ncRNA review |
| 基金项目:国家自然科学基金（82060167);云南省教育厅教师类项目（2023J0304）；玉溪市人民医院院内项目研究生类（yys2024-01） |
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| 中文摘要: |
| 骨质疏松症（osteoporosis，OP）是一种由多因素引发的骨骼疾病，主要表现为骨量减少、骨微结构损坏等，使得骨脆性增加，加大发生骨折的风险及概率。在OP发生中，微小RNA（microRNA，miRNA）和环状RNA（circular RNA，circRNA）等非编码RNA（non code RNA，NCRNA）在基因表达调控上扮演着重要角色。在骨代谢中，circRNA和miRNA可相互作用，有调控成骨细胞及破骨细胞分化的功能；此外，circRNA可作为miRNA海绵体，调控相关基因的表达水平。本文探讨了circRNA-miRNA网络在骨质疏松症中的研究进展，旨在深入了解其调控机制和应用前景，为骨质疏松诊断、治疗和评估提供新思路，并促进该领域的发展。 |
| 英文摘要: |
| Osteoporosis (OP) is a multifactorial bone disorder characterized by a decrease in bone mass and deterioration of bone mi-crostructure. These pathological features contribute to increased bone fragility and a heightened risk of fracture. In OP pathogenesis, non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and circular RNAs (circRNAs), play crucial roles in gene expression regulation. CircRNAs and miRNAs interact to modulate the differentiation of osteoblasts and os-teoclasts. Additionally, circRNAs function as miRNA sponges, thereby influencing the expression levels of target genes. This review examines recent advances in circRNA-miRNA networks related to osteoporosis, aiming to elucidate their regu-latory mechanisms and potential applications. This exploration seeks to offer novel insights into diagnosis, treatment, and evaluation strategies, ultimately advancing the field. |
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