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| 血管内皮功能障碍、炎症和骨病理的关联 |
| The relationship among vascular endothelial dysfunction, inflammation, and bone pathology |
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| DOI：10.3969/j.issn.1006-7108.2025.06.023 |
| 中文关键词: 内皮功能障碍；炎症；骨病理 综述 |
| 英文关键词:endothelial dysfunction inflammation bone pathology review |
| 基金项目:河南省二〇二三年科技发展计划项目( 232102311219) ；国家自然科学基金面上项目（82074472） |
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| 中文摘要: |
| 探索血管内皮功能障碍、炎症与骨病理之间的关系具有重要意义，其不仅关乎理解多种疾病的发病机制，并且对发现新的骨科疾病治疗方法和预防策略至关重要。骨内存在大量微血管，内皮细胞（ECs）直接参与血液动力学的调节、血管的舒缩以及血栓形成的防治，对骨病理的发生与发展起到关键作用。同时，炎症作为身体对疾病或损伤的自然反应，在控制感染和促进损伤修复方面发挥着关键作用。然而，持续的炎症状态与多种慢性疾病的发展有关，包括骨质疏松症和其他骨病理条件。本文深入综述了内皮功能障碍、炎症与骨病理之间的关系，以期为骨科医学发展和改善骨科患者护理方式提供依据。 |
| 英文摘要: |
| Exploring the relationship among vascular endothelial dysfunction, inflammation, and bone pathology is of great significance, which is not only related to understanding the pathogenesis of multiple diseases, but also crucial for discovering new orthopedic disease treatment methods and prevention strategies. There are a large number of microvessels in bone. Endothelial cells (ECs) are directly involved in the regulation of hemodynamics, the contraction of blood vessels, and the prevention and treatment of thrombosis, which play a key role in the occurrence and development of bone pathology. At the same time, inflammation, as the body's natural response to disease or injury, plays a key role in controlling infection and promoting damage repair. However, persistent inflammatory states are associated with the development of a variety of chronic diseases, including osteoporosis and other osteopathological conditions. This article reviews the relationship among endothelial dysfunction, inflammation, and bone pathology, in order to provide a basis for the development of orthopedic medicine and the improvement of orthopedic patient care. |
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