| Objective To analyze the effects of intermittent fasting method supplemented with western medicine symptomatic treatment on body weight and glucose-lipid metabolism, pancreatic β-cell function indexes, and bone remodeling markers in patients with T2DM and osteoporosis. Methods 200 patients with T2DM and osteoporosis were selected on an elective basis from 2021.01-2024.06, and were randomly divided into a control group and an observation group, with 100 cases in each group, and were treated with Western medicine symptomatic therapy and intermittent fasting method combined with Western medicine symptomatic therapy, respectively. Body weight, bone density, glucose-lipid metabolism, pancreatic β-cell function indexes and bone remodeling markers were compared between the two groups. Results BMI, FBG, 2 h PBG, and TC, TG were significantly lower in the observation group compared with the control group (P<0.05), indicating that the patients' body weight and glucose-fat metabolism were significantly restored; compared with the control group, the pancreatic islet β-cell function index (HOMA-β) was significantly higher in the observation group, and the insulin resistance index (HOMA-IR) was significantly lower (P<0.05); compared with the control group, the observation group Lumbar spine, femoral neck and ulnar radius bone density were significantly increased (P<0.05); after the intervention, compared with the control group, the BGP of the observation group was significantly increased and TRAP-5b was significantly decreased, indicating that the activity of osteoclasts in the patients was inhibited and bone formation was active (P<0.05). Conclusion Intermittent fasting method supplemented with western medicine symptomatic treatment for T2DM with osteoporosis patients can significantly control body weight, regulate body sugar and lipid metabolism, promote the repair of pancreatic islet β-cell function and the effect of bone mineral density enhancement is exact. |