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| 胆汁酸受体FXR和TGR5在骨代谢调控中的作用机制 |
| Research on the mechanisms of bile acid receptors FXR and TGR5 in regulating bone metabolism |
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| DOI：10.3969/j.issn.1006-7108.2025.07.015 |
| 中文关键词: 法尼醇X受体 武田G蛋白偶联受体5 骨代谢 胆汁酸受体 |
| 英文关键词:FXR TGR5 bone metabolism bile acid receptor |
| 基金项目:国家自然科学基金（82060152） |
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| 中文摘要: |
| 胆汁酸受体作为关键的代谢调节因子，在维持机体稳态中扮演着重要角色。这类受体不仅参与糖脂代谢的精细调控，还广泛影响多种生理过程。近期研究揭示了胆汁酸受体与骨代谢之间存在密切关联。值得关注的是，法尼醇X受体（farnesoid X receptor，FXR）和武田G蛋白偶联受体5（takeda G protein-coupled receptor 5，TGR5）在骨组织中的广泛表达，这一现象提示它们可能在骨代谢过程中发挥重要的调控作用。然而，FXR与TGR5调控骨代谢的具体分子机制尚未完全阐明。该文通过总结FXR和TGR5在骨代谢调控作用中的研究现状，旨在为骨代谢疾病的治疗提供新的理论基础和创新思路。 |
| 英文摘要: |
| Bile acid receptors function as crucial metabolic regulators and play a significant role in maintaining body homeostasis. These receptors are not only involved in the fine-tuning of glucose and lipid metabolism but also widely influence various physiological processes. Recent studies have revealed a close association between bile acid receptors and bone metabolism. Notably, the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5) are widely expressed in the bone tissue, suggesting that they may play significant regulatory roles in bone metabolism. However, the specific molecular mechanisms by which FXR and TGR5 regulate bone metabolism have not yet been fully elucidated. This article summarizes the current research status of FXR and TGR5 in the regulation of bone metabolism, aiming to provide new theoretical basis and innovative ideas for the treatment of bone metabolism diseases. |
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