| In the process of bone metabolism, iron serves as a crucial cofactor, engaging in catalytic reactions of various enzymes, thereby influencing both bone formation and bone resorption. Ferroptosis, a novel non-apoptotic mode of cell death characterized by intracellular iron accumulation and lipid peroxidation, has emerged in recent years. Osteoporosis (OP) often coexists with chronic low-grade inflammation, which may induce ferroptosis, further damaging bone cells in this inflammatory milieu. However, since both bone and immune cells originate from the bone marrow and share the same microenvironment, current research suggests that alterations in iron content under inflammatory conditions impact the functionality of immune cells, directly or indirectly participating in the process of bone remodeling. Therefore, based on osteoimmunology, this review explores the role of ferroptosis-mediated immune regulation in osteoporosis, aiming to provide a new perspective for the treatment of OP. |