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| 线粒体通过介导骨髓间充质干细胞影响骨代谢的机制 |
| The mechanism of mitochondria influence bone metabolism by mediating bone marrow mesenchymal stem cells |
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| DOI：10.3969/j.issn.1006-7108.2025.07.023 |
| 中文关键词: 线粒体 骨髓间充质干细胞 线粒体自噬 骨代谢 |
| 英文关键词:mitochondria bone marrow mesenchymal stem cells mitochondrial autophagy bone metabolism |
| 基金项目:国家自然科学基金（81973878）；江苏省中医退行性骨关节疾病临床创新中心（2021040501）；无锡市“双百”中青年医疗卫生拔尖人才项目（BJ2023069） |
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| 中文摘要: |
| 线粒体是位于大多数真核细胞中被双层膜包被的细胞器，它的代谢和调节功能对细胞的生命活动至关重要。线粒体功能是以组织特异性方式随着年龄的增长而改变的，因此可以认为线粒体是引起大多数与年龄相关的退行性疾病的元凶，毫无疑问，骨质疏松与年龄以及细胞衰老息息相关。近年来，越来越多的研究证实，线粒体功能异常会通过影响骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）中不同的细胞因子和蛋白表达，调控BMSCs的成骨分化及凋亡过程。本文从线粒体自噬、线粒体动力学、线粒体氧化应激、线粒体生物发生和线粒体铁死亡5个方面，详细介绍了线粒体质量控制调控BMSCs成骨分化的分子机制，旨在为骨质疏松的治疗提供新的研究思路。 |
| 英文摘要: |
| Mitochondria are organelles in most eukaryotic cells, and their metabolic and regulatory functions are essential for cell life activities. Mitochondrial function changes with age in tissue-specific ways, so mitochondria are believed to be responsible for most age-related degenerative diseases. There is no doubt that osteoporosis is closely related to age and cellular senescence. In recent years, more and more studies have confirmed that mitochondrial dysfunction can regulate the osteoblastic differentiation and apoptosis of bone marrow-derived mesenchymal stem cells (BMSCs) by affecting the expression of different cytokines and proteins in BMSCs. In this paper, the molecular mechanism of mitochondrial quality control regulating osteogenic differentiation of BMSCs was introduced in detail from five aspects: mitochondrial autophagy, mitochondrial dynamics, mitochondrial oxidative stress, mitochondrial biogenesis and mitochondrial iron death, aiming to provide new research ideas for the treatment of osteoporosis. |
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