| Bone metabolism homeostasis is crucial for the maintenance of bone homeostasis, and when this balance is disrupted, it not only increases the risk of fracture, but also leads to the development of a variety of bone metabolic diseases. Therefore, exploring the regulatory mechanisms of bone metabolism is important for maintaining bone health. Currently, the regulation of hormones in bone metabolism has become a research hotspot, among which Preptin, as a new type of peptide hormone, not only has a positive value in the regulation of glucose and lipid metabolism, insulin resistance and inflammatory response, but also has a close relationship with bone metabolism. In recent years, it has been found that Preptin can regulate bone metabolism by promoting bone formation and inhibiting bone resorption, which involves the signaling pathways of ERK/CTGF, Wnt/β-catenin, and PLC/PKC, suggesting that Preptin may be a potential target for the regulation of bone metabolism homeostasis. Considering that there is no study that systematically summarizes the biological mechanism of Preptin in regulating bone metabolism, this paper systematically summarizes the studies related to Preptin and bone metabolism, and analyzes the possible mechanisms of Preptin in regulating bone metabolism, with a view to providing new theoretical basis for improving bone metabolic diseases. |