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| 内质网-线粒体轴在骨质疏松症中的研究进展 |
| Research progress of endoplasmic reticulum-mitochondrial axis in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2025.08.016 |
| 中文关键词: 骨质疏松症 内质网-线粒体轴 骨组织细胞 钙稳态 |
| 英文关键词:osteoporosis endoplasmic reticulum-mitochondrial axis bone histocyte calcium homeostasis |
| 基金项目:甘肃省联合科研基金项（24JRRA878）；甘肃省省级人才项目（2025RCXM006）；甘肃省自然科学基金项目（24JRRA1020）；甘肃省科技计划项目重点研发计划国际科技合作类（25YFWA024） |
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| 中文摘要: |
| 骨质疏松症（osteoporosis，OP）是一种常见的代谢性骨病，其主要特征为骨量减少和骨组织微结构退化，导致骨脆性增加，显著提高骨折风险。近年来的研究表明，内质网-线粒体轴（ER-mitochondria contact sites, ERMCS）在OP的发生和发展中发挥了重要作用。内质网和线粒体是细胞内两个关键的细胞器，通过紧密的物理和功能联系，共同参与细胞代谢、钙稳态和细胞凋亡等核心过程。特别是ERMCS接触部位，在维持内质网和线粒体功能协调方面具有至关重要的作用。本文将综述ERMCS在OP研究中的最新进展，重点探讨其在成骨细胞、破骨细胞以及骨髓间充质干细胞功能调控中的作用，并分析相关的信号通路和分子机制，旨为OP的诊断和治疗提供了新的思路和潜在的靶点。 |
| 英文摘要: |
| Osteoporosis is a prevalent metabolic bone disorder marked by a reduction in bone mass and deterioration of the bone tissue microarchitecture, leading to heightened bone fragility and a significantly increased risk of fractures. Recent research has demonstrated that the endoplasmic reticulum-mitochondrial axis is pivotal in the pathogenesis and progression of osteoporosis. The endoplasmic reticulum and mitochondria are essential organelles within the cell, playing key roles in cellular metabolism, calcium homeostasis, and apoptosis through intricate physical and functional interconnections. Notably, ER-mitochondria Contact Sites (ERMCS) are critical for sustaining the functional coordination between these two organelles. This paper reviews recent advances in understanding the role of the endoplasmic reticulum-mitochondrial axis in osteoporosis, with a particular emphasis on its regulatory effects on osteoblasts, osteoclasts, bone marrow mesenchymal stem cells, and osteocytes, and examines the associated signaling pathways and molecular mechanisms, aiming to offer novel insights and potential therapeutic targets for the diagnosis and treatment of osteoporosis. |
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