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| 线粒体相关功能障碍在骨代谢研究中的作用机制进展 |
| Progress in the mechanism of mitochondrial related dysfunction in bone metabolism |
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| DOI：10.3969/j.issn.1006-7108.2025.08.019 |
| 中文关键词: 线粒体 线粒体DNA 线粒体膜电位 骨代谢 骨质疏松 |
| 英文关键词:mitochondria mitochondrial DNA mitochondrial membrane potential bone metabolism osteoporosis |
| 基金项目:国家自然科学基金（81973878）；江苏省中医退行性骨关节疾病临床创新中心项目（2021040501）；无锡市“双百”中青年医疗卫生拔尖人才项目（BJ2023069） |
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| 中文摘要: |
| 线粒体是大多数真核细胞中被双层膜包被的细胞器，其拥有复杂的细胞结构，这些细胞结构能协调各种组织功能，维持成骨细胞和破骨细胞的分化和增殖，当这些结构发生异常时，则会影响机体的骨代谢过程。其中线粒体DNA（mtDNA）突变、线粒体膜电位（ΔΨm）变化、线粒体氧化磷酸化（oxidative phosphorylation，OXPHOS）异常和线粒体钙单向转运体（mitochondrial Ca2+ uniporter，MCU）转运是调节骨代谢的重要途径。因此，该文从以上线粒体的4个角度详细介绍了近年来其与骨代谢的相关研究及最新进展，旨在为骨质疏松的治疗提供新的研究思路。 |
| 英文摘要: |
| Mitochondria are the organelles in most eukaryotic cells, which are covered by double membranes. They have complex cellular structures, which coordinate various tissue functions and maintain the differentiation and proliferation of osteoblasts and osteoclasts. When these structures are abnormal, they will affect the bone metabolism process of the body. Mitochondrial DNA (mtDNA) mutation, mitochondrial membrane potential (ΔΨm) change, mitochondrial oxidative phosphorylation (OXPHOS) abnormality, and mitochondrial Ca2+ uniporter (MCU) are important pathways in the regulation of bone metabolism. Therefore, from the above four perspectives, this paper introduces the recent research in mitochondria and osteoporosis and the latest progress in detail, aiming to provide a new research idea for the treatment of osteoporosis. |
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