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| miRNA调控VEGF/NOTCH信号通路在成骨细胞增殖分化中的作用机制研究进展 |
| Research Progress on the Mechanisms of miRNA Regulation in Osteoblast Proliferation and Differentiation via the VEGF/NOTCH Signaling Pathway |
| 投稿时间：2025-09-18 修订日期：2025-11-11 |
| DOI： |
| 中文关键词: 骨质疏松 miRNA VEGF/NOTCH信号通路 成骨增殖 成骨分化 |
| 英文关键词:Osteoporosis miRNA VEGF/NOTCH signaling pathway Osteoblast proliferation Osteoblast differentiation. |
| 基金项目:内蒙古自治区公立医院科研联合基金项目（2024GLLH0559） |
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| 中文摘要: |
| 骨质疏松症(osteoporosis,OP)作为一种以骨代谢失衡为特征的疾病,其发生与成骨细胞(osteoblast,OB)增殖分化异常密切相关。目前,VEGF/Notch信号通路在骨代谢中扮演着关键角色,二者在骨微环境中存在动态交互,影响成骨细胞的增殖分化。而微小RNA(miRNAs)作为转录后调控的关键分子,通过靶向双通路关键节点形成复杂调控网络从而影响成骨细胞增殖分化,成为调控骨代谢的新兴研究焦点。本综述系统总结了miRNAs调控VEGF/NOTCH双信号通路在成骨细胞功能中的分子机制及其病理意义。旨在指出当前研究中的挑战与未来方向,为后续研究及临床应用提供参考和启示。 |
| 英文摘要: |
| Osteoporosis (OP), a disease characterized by bone metabolism imbalance, is closely associated with abnormal proliferation and differentiation of osteoblasts (OB). Currently, the VEGF/Notch signaling pathway plays a crucial role in bone metabolism, with dynamic interactions between these two pathways in the bone microenvironment that influence osteoblast proliferation and differentiation. As key post-transcriptional regulatory molecules, microRNAs form complex regulatory networks through targeting critical nodes of both pathways, making them emerging research focuses in bone metabolism regulation. This review systematically summarizes the molecular mechanisms and pathological significance of miRNAs regulating the VEGF/NOTCH dual signaling pathways in osteoblast function. It aims to highlight current research challenges and future directions, providing references and insights for subsequent studies and clinical applications. |
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