|
| 原发性肾病综合征患儿骨代谢指标与IGF-1、25(OH)D的相关性 |
| The correlation between bone metabolism indexes and IGF-1 and 25 (OH) D in children with primary nephrotic syndrome |
| |
| DOI：10.3969/j.issn.1006-7108.2025.10.008 |
| 中文关键词: 原发性肾病综合征 儿童 骨代谢 胰岛素样生长因子 25-羟基维生素D |
| 英文关键词:primary nephrotic syndrome children bone metabolism insulin-like growth factor 25-hydroxyvitamin D |
| 基金项目: |
|
| 摘要点击次数: 1 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 探讨原发性肾病综合征（PNS）患儿骨代谢指标与胰岛素样生长因子（IGF-1)、25-羟基维生素D[25(OH)D]间的关系。方法 收集2020年5月至2024年5月收治的72例PNS患儿临床资料（简称PNS组），同期收集健康体检儿童72例临床资料（简称健康组）。PNS患者均采用糖皮质激素、营养干预、维生素D联合钙剂治疗，比较两组儿童血清IGF-1、25(OH)D与骨代谢相关指标，采用Pearson分析IGF-1、25(OH)D与骨代谢指标相关性。结果 PNS组血清IGF-1、25(OH)D、血钙、骨钙素（BGP）、骨保护素（OPG）、骨碱性磷酸酶（BALP）、Ⅰ型胶原氨基端延长肽（P1NP）低于健康组（P<0.05），血清Ⅰ型胶原交联C-末端肽（CTX）、抗酒石酸酸性磷酸酶5b（TRACP5b）高于健康组（P<0.05）。随着治疗时间延长，PNS组血清IGF-1、25(OH)D、钙、BGP、OPG、BALP升高，血清CTX、TRACP5b降低，差异有统计学意义（P<0.05）。血清IGF-1及25(OH)D与钙（r=0.261, 0.243, P<0.05）、BGP（r=0.289, 0.294, P<0.05）、OPG（r=0.315, 0.342, P<0.05）、BALP（r=0.456, 0.427, P<0.05） 呈正相关，与CTX（r=?0.523, ?0.464, P<0.05）、TRACP5b（r=?0.812, ?0.745, P<0.05）呈负相关。结论 PNS患儿血清IGF-1、25(OH)D水平低下，与骨代谢障碍明显相关。应加强对PNS患儿血清IGF-1、25(OH)D水平的监测及研究，探讨其在PNS患儿发病机制中的作用，为PNS患儿临床诊断及治疗评估提供参考。 |
| 英文摘要: |
| Objective To investigate the relationship between bone metabolism and insulin-like growth factor (IGF-1) and 25-hydroxyvitamin D [25(OH)D] in children with primary nephrotic syndrome (PNS). Methods The clinical data of 72 PNS children admitted from May 2020 to May 2024 were collected (PNS group). The clinical data of 72 healthy children during the same period were collected (healthy group). PNS patients received glucocorticoids, nutritional interventions, vitamin D, and calcium supplements. The serum levels of IGF-1, 25(OH)D, and bone metabolism indicators were compared between the two group. The correlation between IGF-1, 25(OHD), and bone metabolism indicators was analyzed using Pearson analysis. Results Serum levels of IGF-1, 25(OH)D, Ca, BGP, OPG, BALP, and P1NP in PNS group were lower than those in healthy group (P<0.05), but levels of CTX and TRACP5b were higher than those in healthy group (P<0.05). As the treatment time prolongs, serum levels of IGF-1, 25(OH)D, Ca, BGP, OPG, and BALP in PNS group increased, but serum levels of CTX and TRACP5b decreased (P<0.05). Serum levels of IGF-1 and 25-(OH)D were positively correlated with Ca (r=0.261, 0.243, P<0.05), BGP (r=0.289, 0.294, P<0.05), OPG (r=0.315, 0.342, P<0.05), and BALP (r=0.456, 0.427, P<0.05), but negatively correlated with CTX (r=?0.523, ?0.464, P<0.05) and TRACP5b (r=?0.812, ?0.745, P<0.05). Conclusion Serum levels of IGF-1 and 25(OH)D are low in PNS children. They are significantly associated with bone metabolism disorders. It is important to strengthen the monitor and research on the levels of serum IGF-1 and 25(OH)D, to explore the role in the pathogenesis of PNS in children, and to provide a reference for clinical diagnosis and treatment evaluation of PNS in children. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|