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| 促红细胞生成素对成骨的调控机制及研究进展 |
| The regulatory mechanism and research progress of erythropoietin on bone |
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| DOI：10.3969/j.issn.1006-7108.2025.10.010 |
| 中文关键词: 促红细胞生成素 骨形成 成骨细胞 软骨细胞 信号通路 |
| 英文关键词:erythropoietin bone formation osteoblasts chondrocytes signaling pathways |
| 基金项目:国家自然科学基金（82160193，82460199）；贵州省科技厅基金（黔科合基础-ZK[2022]一般384） |
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| 中文摘要: |
| 在骨缺损的修复中，成骨细胞是骨发育和重塑的关键细胞类型，软骨细胞则在软骨保护和修复中扮演着重要角色，促红细胞生成素对成骨细胞和软骨细胞的功能分化与调控已成为骨缺损修复领域的研究热点。该文旨在综述促红细胞生成素调控成骨细胞和软骨细胞的相关信号通路及其作用机制，为进一步揭示促红细胞生成素对成骨微环境的调控机制提供理论依据，为骨缺损修复领域提供新思路。 |
| 英文摘要: |
| In the repair of bone defects, osteoblasts are the key cell types of bone development and remodeling, and chondrocytes play an important role in cartilage protection and repair. The functional differentiation and regulation of erythropoietin on osteoblasts and chondrocytes has become a research hotspot in the field of bone defect repair. The purpose of this paper is to review the related signaling pathways and mechanisms of erythropoietin in regulating osteoblasts and chondrocytes, to provide a theoretical basis for further revealing the regulatory mechanism of erythropoietin on osteogenic microenvironment, and to provide new ideas for the field of bone defect repair. |
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